Recent Achievements

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Recent Achievements

A Review by Prof Tao Sun and Prof Chen Jiang on Adv Drug Deliv Rev: Simuli-Responsive Drug Delivery Systems Triggered by Intracellular or Subcellular Microenvironments

2023/03/14

Drug delivery systems (DDSs) are important pharmaceutical solutions for optimizing the in vivo drug distribution, where DDSs triggered by local microenvironment represents the state-of-art of nanomedicine design. Currently, the hot topics are mainly concerning the long circulation, fine tumor targe...

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Prof. Renxiao Wang's group has discovered novel small-molecule autophagy inhibitors by targeting the protein-protein interactions involving ATG5

2023/02/17

Autophagy is a process of cellular scavenging that relies on lysosomes, whereby protein aggregates and damaged organelles are broken down. This process is evolutionarily conserved and serves to maintain cellular homeostasis, as well as promote cell survival in the face of stressors. Through the degr...

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Professor Yan Li 's Research Group Has Made New Progress in the Field of Rapid Quality Assessment of Therapeutic Antibodies

2022/11/04

Recently, the research group of Professor Yan Li from the Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University published a research article entitled “A Tractable Method for Rapid Quality Assessment of Therapeutic Antibodies in Harvested Cell Culture Fluid Based on FcγRIIIa I...

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Progress in the field of biosensing platform in the NIR-II Window from Lei Zuhai's research group

2022/11/04

Lei Zuhai's research group at the School of Pharmacy has made progress in the field of fluorescence biosensing in the second near-infrared window (NIR-II). The research project constructed a NIR-II molecular platform, which can be conveniently developed for various activatable ratiometric NIR-II mol...

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Recent progress in the research of against drug-resistant breast cancer antagonists with collateral sensitivity by Professor Ying Chen’s group and Associate Professor Hongrui Liu’s group

2022/07/01

Recently, Professor Ying Chen’s Group (Department of Pharmaceutical Chemistry) and Associate Professor Hongrui Liu’s Group (Department of Pharmacology) published an article entitled “Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensi...

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Prof. Tao Sun and Chen Jiang's group has made progress in overcoming the stromal barrier in the treatment of pancreatic cancer

2022/05/06

Along with an increased global incidence, pancreatic cancer (PDAC) shows the worst prognosis, a 5-year survival rate of less than 5%. Despite ongoing research, PDAC has developed greater drug resistance due to its prominent feature of connective tissue proliferation in the mesenchyme, which raises i...

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Recent progress in the development of a synergistic strategy to improve dyes for nanoscopy from Lu Wang’s group

2022/04/28

Lu Wang’s group in the School of Pharmacy, Fudan University, and Lin Yuan’s Group in Hunan University have developed a synergistic strategy to develop photostable and bright dyes with long Stokes shift for super-resolution microscopy. The study was published in the Nature Communications (https://w...

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Repurposing interferon-alpha, a novel immunotherapy strategy in hepatocellular carcinoma (HCC)

2022/04/25

Interferon-alpha (IFN-α) has long been used in clinical practice. In 1986, IFN-α was first approved by the U.S. Food and Drug Administration (FDA) as a tumor immunotherapy drug to treat hairy cell leukemia. Till now, IFN-α has been widely approved across the world for treatment of a variety of ma...

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Recent progress in the discovery of novel A2AR antagonists by Yonghui Wang’s group

2022/03/25

Recently, Yonghui Wang’s group (School of Pharmacy, Fudan University) and Weiqiang Lu’s group (School of Life Science, ECNU) published an article entitled ‘Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer I...

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Prof. Xuemei Zhang’s group revealed a novel role of BK potassium channel activity in preventing the development of kidney fibrosis

2022/03/18

Recently, a paper titled “A novel role of BK potassium channel activity in preventing the development of kidney fibrosis” was published on the internationally renowned academic journal “Kidney International”. The research was completed by Xuemei Zhang’s group (School of pharmacy, Fudan Universi...

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Killing two birds with one stone: Versatile Rg3 liposomes inhibit tumor metastasis by destroying the metastatic “seeds” and “soil”

2022/02/15

Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and is more likely to metastasize than other breast cancer subtypes. Metastasis accounts for over 90% of TNBC-caused mortality in women. The process of tumor metastasis is complex. The seed and soil theory is widely re...

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Intelligent SERS surgery navigation system intraoperatively delineating the acidic margins of brain tumor

2022/01/15

Surgeons face challenges in intraoperatively defining margin of brain tumors due to its infiltrative nature. Extracellular acidosis caused by metabolic reprogramming of cancer cells is a reliable marker for tumor infiltrative regions. There is a spatiotemporal correlation between tissue acidity and ...

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Recent progress in the discovery of RORγt/DHODH dual inhibitors by Yonghui Wang’s group and Jin Huang’s group (ECUST)

2022/01/07

Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated gastrointestinal disease with complex etiology. The incidence and prevalence of IBD have increased rapidly in developing countries over the past few years. High recurrence rate and severe complications have brought great challe...

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Prof. Jianxin Wang's group makes progress in the field of tumor immunochemotherapy combination therapy

2022/01/06

Recently, Prof. Jianxin Wang's group has developed a dendritic cell (DC) bionanotropic nano-formulation that enables immunochemotherapy combination therapy and amplifies the tumor immune response effect with significant anti-tumor effects. The study has been published in the internationally renowned...

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Professor Xiaoyan Shen’s group disclosed a new mechanism of intestinal epithelial barrier dysfunction in inflammatory bowel disease

2021/11/19

Inflammatory bowel disease (IBD) is a chronic, recurrent intestinal inflammatory disease of unknown pathogenesis, including ulcerative colitis (UC) and Crohn's disease (CD). The global incidence of IBD remains high, and China is the country with the highest incident rate of IBD (3.44 per 100,000 per...

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Progress in the field of in vivo biosensing in the NIR-II window from Zuhai Lei's group

2021/10/13

Zuhai Lei's group at the School of Pharmacy and Fan Zhang's group at the Department of Chemistry, Fudan University have made progress in the field of near-infrared II (NIR-II) in vivo fluorescence biosensing. The research project has developed a series of novel NIR-II fluorescent dyes, which can be ...

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Prof. Renxiao Wang’s group cooperated with Hong Kong Polytechnic University to obtain stapled peptides targeting Beclin 1

2021/10/08

Beclin 1 is the scaffolding member of the Class III phosphatidylinositol-3-kinase (PI3KC3) complex and recruits two positive regulators Atg14L and UVRAG through its coiled-coil domain to upregulate PI3KC3 activity. Deficiency or dysfunction of Beclin 1 has been linked to human pathologies such as ca...

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Recent progress of Jin-Feng Hu/Juan Xiong’s group in the discovery of novel lipogenesis inhibitors from the rare and endangered conifers endemic to China

2021/09/16

Plant derived natural products have continued to play a significant role in the drug discovery and development process. The opportunity for identifying new chemical entities (NCEs) for emerging diseases depends on a diversity of drug-producing species. Plant diversity loss significantly exacerbated...

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Ping Yang's group has made progress in the study of the effect and mechanism of gypenosides on TMAO circulatory pathway

2021/09/15

Trimethylamine-N-oxide (TMAO) has emerged as a promising new therapeutic target for the treatment of central nervous system diseases, atherosclerosis and other diseases. However, its origin in the brain is unclear. Gynostemma pentaphyllum (Thunb.) Makino can reduce the increase of TMAO level caused ...

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New progress in fluorescent probes for imaging intracellular proteins with super-resolution microscopy

2021/09/08

Lu Wang’s group in the School of Pharmacy, Fudan University, and Kai Johnsson’s Group in Max Planck Institute for Medical Research have developed a new strategy for synthesizing fluorescent probes for super-resolution microscopy. The new strategy can transform the same rhodamine into either a high...

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A Review by Prof Tao Sun and Prof Chen Jiang on Adv Drug Deliv Rev: Simuli-Responsive Drug Delivery Systems Triggered by Intracellular or Subcellular Microenvironments

Prof. Renxiao Wang's group has discovered novel small-molecule autophagy inhibitors by targeting the protein-protein interactions involving ATG5

Professor Yan Li 's Research Group Has Made New Progress in the Field of Rapid Quality Assessment of Therapeutic Antibodies

Progress in the field of biosensing platform in the NIR-II Window from Lei Zuhai's research group

Recent progress in the research of against drug-resistant breast cancer antagonists with collateral sensitivity by Professor Ying Chen’s group and Associate Professor Hongrui Liu’s group

Prof. Tao Sun and Chen Jiang's group has made progress in overcoming the stromal barrier in the treatment of pancreatic cancer

Recent progress in the development of a synergistic strategy to improve dyes for nanoscopy from Lu Wang’s group

Repurposing interferon-alpha, a novel immunotherapy strategy in hepatocellular carcinoma (HCC)

Recent progress in the discovery of novel A2AR antagonists by Yonghui Wang’s group

Prof. Xuemei Zhang’s group revealed a novel role of BK potassium channel activity in preventing the development of kidney fibrosis

Killing two birds with one stone: Versatile Rg3 liposomes inhibit tumor metastasis by destroying the metastatic “seeds” and “soil”

Intelligent SERS surgery navigation system intraoperatively delineating the acidic margins of brain tumor

Recent progress in the discovery of RORγt/DHODH dual inhibitors by Yonghui Wang’s group and Jin Huang’s group (ECUST)

Prof. Jianxin Wang's group makes progress in the field of tumor immunochemotherapy combination therapy

Professor Xiaoyan Shen’s group disclosed a new mechanism of intestinal epithelial barrier dysfunction in inflammatory bowel disease

Progress in the field of in vivo biosensing in the NIR-II window from Zuhai Lei's group

Prof. Renxiao Wang’s group cooperated with Hong Kong Polytechnic University to obtain stapled peptides targeting Beclin 1

Recent progress of Jin-Feng Hu/Juan Xiong’s group in the discovery of novel lipogenesis inhibitors from the rare and endangered conifers endemic to China

Ping Yang's group has made progress in the study of the effect and mechanism of gypenosides on TMAO circulatory pathway

New progress in fluorescent probes for imaging intracellular proteins with super-resolution microscopy